openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-23
Macrophage-instructed GSDME couples glioblastoma cell-state plasticity with inflammatory cell death
Yihan Yang, Jonathan Sai‐Hong Chui, Ellen Vervoort, Julie Van Nieuwenhuyze, Shikang Zhao, Carmen Bravo González‐Blas, et al.
Glioblastoma (GBM) cell states reflect spatial microenvironmental interactions. Here, using COMET spatial proteomics and RNAscope across multiregional human GBM tissue, spanning tumor cores with pseudopalisading regions, infiltrative margins and peripheral regions, together with…