openalexCell Communication and Signaling2026-07-24
Lactylation in cancer: a new frontier in metabolic-epigenetic regulation and clinical practice
Yihan Zhang, Lan Chen, Yaxi Qin, Yuxing Wang, Xi Liu, Minghui Zhang, et al.
The discovery of lysine lactylation (Kla) redefines lactate from a passive glycolytic by-product into a bioactive metabolic mediator that directly links cellular metabolism to epigenetic regulation. This emerging post-translational modification dynamically alters histone and non-…