Reinforcement learning (RL) for non-verifiable instruction following increasingly relies on LLM judges with prompt-specific rubrics as reward signals. While recent methods adapt these rubrics to the evolving policy during training, the training prompts themselves remain static, d…
We propose PRECEDE, a precedent-guided co-scientist for side-effect-aware drug redesign that revises a parent compound to mitigate a specified side effect while preserving therapeutic function. Rather than isolated molecular generation, PRECEDE frames redesign as evidence-grounde…
Probabilistic downscaling is the task of modeling the conditional distribution of high-resolution fields given coarse inputs, and is a central challenge to atmospheric science, climate modeling, and other multiscale physical systems. A widely used paradigm decomposes the problem…