We propose PRECEDE, a precedent-guided co-scientist for side-effect-aware drug redesign that revises a parent compound to mitigate a specified side effect while preserving therapeutic function. Rather than isolated molecular generation, PRECEDE frames redesign as evidence-grounded reasoning over drug--side-effect associations, biomedical knowledge graphs, and precedents of safety-driven optimization, coordinated by an LLM orchestrator with explicit policies and human-review checkpoints. We position PRECEDE as a human-supervised AI-for-science workflow in which hypotheses remain auditable, falsifiable, and bounded by prior pharmacology.
MEMEs are widely used on the internet and often carry strong elements of sarcasm or irony. Understanding their hidden meanings typically requires a joint interpretation of text and vision. Existing methods focus on the dual-stream vision-language model to extract the visual and t…
Geometry Foundation Models (GFMs) have substantially advanced monocular 3D reconstruction, yet extending this capability to 4D dynamic understanding remains a fundamental challenge. Most existing motion perception methods (e.g., sparse tracking, dense point-wise flow) treat motio…
To effectively integrate AI into high-stakes, critical environments such as healthcare, autonomous driving, and aviation--and to advance toward higher levels of automation and seamless human-AI collaboration--building trust in AI-driven solutions is essential. Trust, in turn, is…
Multimodal chain-of-thought (CoT) reasoning integrates visual and textual cues through step-by-step inference. In small models with limited token budgets, modality-interaction fusion often suppresses tiny cross-modal differences. In particular, multimodal CoT often struggles when…
We show how large-deviation statistics allows one to obtain reliable estimates of the multiplicity of stable fixed-points in a model of neural ordinary differential equations previously employed in computational tasks. The result is obtained by developing a suitable perturbative…
Singular value soft-thresholding can be computed via a reduction to the matrix polar decomposition, which allows one to exploit GPU-friendly algorithms for computing the polar decomposition. Empirically, there is a significant speed-up on GPUs compared to the standard approach us…