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arxiveess.SYq-bio.QM2026-07-15

Exact Decomposition of Adversarial Dual-Objective Value Functions, with Applications to Optimal Drug Dosing

Dylan Hirsch, William Sharpless, Sylvia Herbert

Hamilton-Jacobi Reachability (HJR) is a central framework in safe control theory. While HJR has traditionally focused on a few fundamental tasks, there is increasing interest in scaling to more complex objectives. Recent works have studied the exact decomposition of the value functions for two fundamental dual-objective tasks in the adversary-free setting. However, not all value function decompositions in HJR remain valid with an adversary. In this work, we develop theoretical approaches to certify that for these two composite value functions, the proposed decompositions still hold with an adversary. Finally, we show how these results can solve issues that arise when applying HJR to optimal drug regimen design.

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